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Sobre la RTICC 2013-2016 » Work Packages

The list of Scientific Programs contemplated in this proposal for a new cancer RETIC sponsored by ISCIII for the period 2013-2016 represents a natural evolution of the previously experienced vertical research Lines and horizontal Platforms held in the context of the Cooperative Cancer research networks active in Spain since 2003.

Indeed, the Executive committees of the prior RTICC editions have always endeavored to review and modify their research programs with an aim at improving the quantity and quality of the cooperative cancer research performed in the RTICCs as well as increasing the ability of the RTICC networked groups to collaborate and compete at the international level. With similar intent, the ISCIII has now included in the current RETIC call a number of additional requisites, not previously contemplated in previous RTICCs, such as the predominantly traslational nature of the research to be performed, the emphasis on bigger size and productivity of the networked groups, and the requirement for a minimum 50% of clinical research groups in the final roster of the network.

Taking into account the above mentioned need for quality improvements and the new selection criteria contained in the ISCIII call, recent deliberations of the Executive Committee of the currently active RTICC produced in January 2012 a suggested list of 8 separate Scientific Programs that is basically coincident with the set of Programs listed for all potential cancer RETIC proposals in the call for new RETIC applications published by SCIII in the BOE issue of March2012.

After defining the specific Programs to be included in the proposal, the CE also designed a detailed calendar and procedure for selection of the most appropriate PI candidates for those Programs in a competitive process open not only to previous members of RTICC but also to PI candidates from other scientific organizations or networks. Interestingly, an important number of groups from the currently active RTICC became fused into a single new group inorder to present their candidacy to this new cancer RETIC. In parallel, the EC also elected a Coordinator for each proposed scientific Program who was put in charge of piloting and managing the preparation of the specific research programs and work packages and defining the expected contributions and matching budgets assigned to each participating group. All these preparations and selection processes were completed at the end of May, and a final list of programs, coordinators and group PIs was released by the EC after its meeting of may 28th.

The list of Programs, Work packages, Coordinator and Group PIs included in this new RETIC on cancer is as follows:

Work Packages
Coordinación RTICC
03/03/2017 | Otras reuniones
13/11/2016 | Otras reuniones
Unveiling changes in the landscape of patient populations in cancer early drug development.
Hierro C, Azaro A, Argilés G, Elez E, Gómez P, Carles J, Rodon J
Oncotarget  2017.  8.  14158-14172.  PMID: 27835915. 

The expanding role of immunotherapy.
Martin-Liberal J, Ochoa de Olza M, Hierro C, Gros A, Rodon J, Tabernero J
Cancer Treat Rev  2017.  74-86.  PMID: 28231560. 

The consensus molecular subtypes of colorectal cancer.
Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, Bot BM, Morris JS, Simon IM, Gerster S, Fessler E, De Sousa E Melo F, Missiaglia E, Ramay H, Barras D, Homicsko K, Maru D, Manyam GC, Broom B, Boige V, Perez-Villamil B, Laderas T, Salazar R, Gray JW, Hanahan D, Tabernero J, Bernards R, Friend SH, Laurent-Puig P, Medema JP, Sadanandam A, Wessels L, Delorenzi M, Kopetz S, Vermeulen L, Tejpar S
Nat Med  2015.  11.  1350-6.  PMID: 26457759. 

Subgroup analysis in RAISE: a randomized, double-blind phase III study of irinotecan, folinic acid, and 5-fluorouracil (FOLFIRI) plus ramucirumab or placebo in patients with metastatic colorectal carcinoma progression.
Obermannová R, Van Cutsem E, Yoshino T, Bodoky G, Prausová J, Garcia-Carbonero R, Ciuleanu T, Garcia Alfonso P, Portnoy D, Cohn A, Yamazaki K, Clingan P, Lonardi S, Kim TW, Yang L, Nasroulah F, Tabernero J
Ann Oncol  2016.  11.  2082-2090.  PMID: 27573561. 

Single-cell transcriptome conservation in cryopreserved cells and tissues.
Guillaumet-Adkins A, Rodríguez-Esteban G, Mereu E, Mendez-Lago M, Jaitin DA, Villanueva A, Vidal A, Martinez-Marti A, Felip E, Vivancos A, Keren-Shaul H, Heath S, Gut M, Amit I, Gut I, Heyn H
Genome Biol  2017.  1.  45.  PMID: 28249587. 

Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients.
Sclafani F, Chau I, Cunningham D, Lampis A, Hahne JC, Ghidini M, Lote H, Zito D, Tabernero J, Glimelius B, Cervantes A, Begum R, De Castro DG, Wilson SH, Peckitt C, Eltahir Z, Wotherspoon A, Tait D, Brown G, Oates J, Braconi C, Valeri N
Carcinogenesis  2016.  9.  852-7.  PMID: 27381831. 

SEOM Clinical Guideline for the treatment of pancreatic cancer (2016).
Vera R, Dotor E, Feliu J, González E, Laquente B, Macarulla T, Martínez E, Maurel J, Salgado M, Manzano JL
Clin Transl Oncol  2016.  12.  1172-1178.  PMID: 27896637. 

Second-line therapy after nab-paclitaxel plus gemcitabine or after gemcitabine for patients with metastatic pancreatic cancer.
Chiorean EG, Von Hoff DD, Tabernero J, El-Maraghi R, Wee Ma W, Reni M, Harris M, Whorf R, Liu H, Shiansong Li J, Manax V, Romano A, Lu B, Goldstein D
Br J Cancer  2016.  9.  e13.  PMID: 27657342. 

Second-line therapy after nab-paclitaxel plus gemcitabine or after gemcitabine for patients with metastatic pancreatic cancer.
Chiorean EG, Von Hoff DD, Tabernero J, El-Maraghi R, Ma WW, Reni M, Harris M, Whorf R, Liu H, Li JS, Manax V, Romano A, Lu B, Goldstein D
Br J Cancer  2016.  2.  188-94.  PMID: 27351217. 

Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action.
Duran I, Lambea J, Maroto P, González-Larriba JL, Flores L, Granados-Principal S, Graupera M, Sáez B, Vivancos A, Casanovas O
Target Oncol  2017.  1.  19-35.  PMID: 27844272. 

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