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INTEGRATION AND JOINT PROGRAM OF ACTIVITIES
The list of Scientific Programs contemplated in this proposal for a new cancer RETIC sponsored by ISCIII for the period 2013-2016 represents a natural evolution of the previously experienced vertical research Lines and horizontal Platforms held in the context of the Cooperative Cancer research networks active in Spain since 2003.
Indeed, the Executive committees of the prior RTICC editions have always endeavored to review and modify their research programs with an aim at improving the quantity and quality of the cooperative cancer research performed in the RTICCs as well as increasing the ability of the RTICC networked groups to collaborate and compete at the international level. With similar intent, the ISCIII has now included in the current RETIC call a number of additional requisites, not previously contemplated in previous RTICCs, such as the predominantly traslational nature of the research to be performed, the emphasis on bigger size and productivity of the networked groups, and the requirement for a minimum 50% of clinical research groups in the final roster of the network.
Taking into account the above mentioned need for quality improvements and the new selection criteria contained in the ISCIII call, recent deliberations of the Executive Committee of the currently active RTICC produced in January 2012 a suggested list of 8 separate Scientific Programs that is basically coincident with the set of Programs listed for all potential cancer RETIC proposals in the call for new RETIC applications published by SCIII in the BOE issue of March2012.
After defining the specific Programs to be included in the proposal, the CE also designed a detailed calendar and procedure for selection of the most appropriate PI candidates for those Programs in a competitive process open not only to previous members of RTICC but also to PI candidates from other scientific organizations or networks. Interestingly, an important number of groups from the currently active RTICC became fused into a single new group inorder to present their candidacy to this new cancer RETIC. In parallel, the EC also elected a Coordinator for each proposed scientific Program who was put in charge of piloting and managing the preparation of the specific research programs and work packages and defining the expected contributions and matching budgets assigned to each participating group. All these preparations and selection processes were completed at the end of May, and a final list of programs, coordinators and group PIs was released by the EC after its meeting of may 28th.
The list of Programs, Work packages, Coordinator and Group PIs included in this new RETIC on cancer is as follows:
1. Program 1. Mecanismos moleculares: caracterización molecular de tumores, genómica del cáncer y biomarcadores/Molecular mechanisms: molecular tumor characterization, cancer genomics and biomarkers
Coordinator: Eugenio Santos
PIs: Santos, Eugenio; Muñoz Terol, Alberto; Crespo Baraja, Piero; Bachs Valldeneu, Oriol; Bonilla Velasco, Félix; Campo Guerri, Elias; López Guillermo, Armando; García Bustelo, Xose Ramón; López Otin, Carlos; Aranda Iriarte, Ana María; Fernández Salguero, Pedro María; López Rivas, Abelardo; Alarcón Sánchez, Balbino; Thomas, George; Carrera Ramírez, Ana Clara
- WP1:Identification of proximal and distal signalling elements with clinically relevant roles in primary tumorigenesis and/or metastasis
- WP2:Use of animal models to identify the pros and cons of new anti-cancer therapies in vivo
- WP3: Development of new therapeutic avenues to inhibit pro-tumorigeneic and/or pro-metastatic signalling routes
- WP4: Corroboration of targets and diagnostic signatures at the clinical level
2. Program 2. Epidemiología y prevención del cáncer / Epidemiology and Cancer Prevention
Coordinator: Borrás Andrés, Josep María
PIs: Bosch José, Francesc Xavier; Gonzalez Svatetz, Carlos Alberto; Malats Riera, Nuria; Borrás Andrés, Josep Maria; Zulueta, Javier; Lázaro García, Concepción; Real Arribas, Francisco; Montuenga Badía, Luis; Capellà Munar, Gabriel; Lacal Sanjuan, Juan Carlos
- WP1 Descriptive epidemiology
- WP2 Genetic and molecular epidemiology
- WP3 Infections and cancer
- WP4 Lifestyle and environmental factors
- WP5 Cancer prevention and control
3. Program 3. Tumores hematológicos / Hematological tumors
Coordinator: Sierra Gil, Jordi
PIs: Bladé Creixenti, Juan; Colomer Pujol, Dolors; Cervantes Requena, Francisco; San Miguel Izquierdo, Jesús Fernando; González Díaz, Marcos; Orfao De Matos Correia E Vale, Jose Alberto; Sierra Gil, Jordi; Piris Pinilla, Miguel Ángel; Sanz Alonso, Miguel Angel; Teixido Calvo, Joaquín; Prosper Cardoso, Felipe; Odero De Dios, María Dolores; Gil Santano, Joan; Solé Ristol, Francesc; Pérez Simón, José Antonio
- WP1 Clonogenic cells
- WP2 Insights into the transformation process from indolent to aggressive forms of the malignancy
- WP3 Identification of prognostic subgroups for risk-adapted therapy
- WP4 Preclinical models of disease as platform for testing targeted therapy
- WP5 Early and late clinical trials with novel agents and new stem cell transplant modalities
4. Programa 4. Cáncer de mama / Breast cancer
Coordinator: Arribas Lopez, Joaquin
PIs: Lluch Hernández, Ana; Pandiella Alonso, Atanasio; Palacios Calvo, José; Arribas López, Joaquín; Albanell Mestres, Joan; Cano García, Amparo; Martín Jiménez, Miguel; Gascón Vilaplana, Pedro; Cruz Cigudosa, Juan; Ramón Y Cajal Agueras, Santiago; García Bustelo, Xose Ramón; Lázaro Garcia, Concepción; Díaz-Rubio García, Eduardo
- WP1 HER2-positive breast cancers
- WP2 Hormone-dependent breast cancers
- WP3 Triple negative tumours
- WP4 Biomarkers
- WP5 Molecular heterogeneity of breast cancers, breast cancer stem cells and cellular plasticity
- WP6 Breast Cancer Metastasis and tumour microenvironment
- WP7 Breast Cancer Genetics and Genetic Counseling
- WP8 Breast Cancer Patient Derived Xenografts
5. Program 5. Cáncer de colon y tracto digestivo / Colorectal and digestive tract tumors
Coordinator: Capellà Munar, Gabriel
PIs: Tabernero Caturla, Josep; Diaz-Rubio Garcia, Eduardo; Carrato Mena, Alfredo; Esteller Badosa, Manel; Batlle, Eduard; Capellà Munar, Gabriel; Garcia De Herreros Madueño, Antonio; Aranda, Enrique; Mollinedo García, Faustino; Real Arribas, Francisco; Bonilla Velasco, Félix; Gonzalez Svatetz, Carlos Alberto; Albanell Mestres, Joan; Santos, Eugenio; Prosper Cardoso, Felipe
- WP1: Discovery of new biomarkers in gastrointestinal tumorigenesis
- WP2: Development of relevant preclinical in vitro and in vivo models with a special emphasis in the identification of predictive markers
- WP3: Personalized risk assessment in GI hereditary cancer syndromes
- WP4: Validation of novel prognostic markers
- WP5: Validation of predictive markers to conventional and targeted therapies in GI cancer
6. Program 6. Cancer vías respiratorias / Lung and respiratory tract tumors
Coordinator: Montuenga Badía, Luis
PIs: Rosell Costa, Rafael; Montuenga Badía, Luis; Sánchez Céspedes, Montserrat; Camps Herrero, Carlos; Paz-Ares, Luis; Lacal Sanjuan, Juan Carlos; Paramio González, Jesús María; Suárez Nieto, Carlos; Borrás Andrés, Josep María; Zulueta, Javier; Esteller, Manel; Albanell Mestres, Joan; Prosper Cardoso, Felipe; Díaz-Rubio García, Eduardo
- WP1: Molecular mechanisms of lung carcinogenesis and metastasis
- WP2: Molecular and genetic profiling of early stage and biomarkers in NSCLC
- WP3: Discovery and preclinical validation of drug targets in LC
- WP4: New therapeutic strategies.
- WP5: Molecular and genetic profiling of metastatic disease for predicting response and resistance to conventional and novel treatments
- WP6: Lung cancer prevention. Screening of lung cancer
7. Program 7. Otros tumores sólidos y pediátricos / Other solid and pediatric tumors
Coordinator: Alava Casado, Enrique De
PIs: Navarro Fos, Samuel; Álava Casado, Enrique de; Sánchez De Toledo Codina, Jose; Reventós Puigjaner, Jaume; Matías-Guiu Guia, Francisco Javier; Prat Diaz De Losada, Jaime; Fernández Luna, Jose Luis; Seoane, Joan; Ramon y Cajal Agueras, Santiago; García Castro, Javier; Palacios Calvo, José; Lázaro García, Concepción; Bosch José Francesc Xavier; Borrás Andrés, Josep Maria
- WP1: Tumours of the nervous system
- WP2: Paediatric tumours
- WP3: Gynaecological tumours, with emphasis in endometrial carcinoma
8. Program 8. Formación y Coordinación / Training and Coordination
Coordinator: Santos, Eugenio
PIs: Santos, Eugenio; Montuenga Badía, Luis; Arribas López, Joaquín; Alava Casado, Enrique De; Borrás Andrés, Josep Maria; Capellà Munar, Gabriel; Sierra Gil, Jordi; Bonilla Velasco, Félix; González Svatetz, Carlos Alberto; San Miguel Izquierdo, Jesús Fernando; Pandiella Alonso, Atanasio; Díaz-Rubio García, Eduardo; Sánchez Céspedes, Montserrat; Reventós Puigjaner, Jaume
The current cancer RETIC proposal plans to actively continue practices already widely held in previous RTICC versions, whereby the Program coordinators and the Executive Committee actively encourage and foster research interactions and collaborations among different RTICC groups, not only within each specific Program but also across the different Programs composing our cancer research network. The results are measurable in terms of the numbers of collaborative publications and competitive projects achieved as well as the number of databases generated and put the service of the scientific community (i.e., databases generated by RTICC on active clinical trial or pediatric tumor data in Spain)
In the current cancer RETIC proposal, it is expected that the inter-Program interactions will involve mainly groups from the more transversal, horizontally-oriented programs. For example, many results generated by the Molecular mechanism program may be useful or applicable to the specific tumors dealt with in the other Programs. Similarly, the Epidemiology program plans to continue offering a platform of service and advice to all investigators participating in the other programs.
All these intra- and inter-Programs collaborations are especially publicized and mentioned in the Annual RTICC meeting (where an annual award is given to the best collaborative publication of the year) and in the Annual reports written by the Program coordinators and the general coordinator.
In addition to performing their research work within the RTICC cancer network, many of our groups are also holding active collaborations outside the RTICC, both at the national and international levels. In the present cancer RETIC proposal, the external collaborations will involve not only individual groups, but also complete Programs, as the tumor oriented Programs have already arranged specific research agreements with various related clinical societies and groups (i.e, Breast Program- GEICAM; Colorectal Program-TTD group; Lung Program-Spanish Lung tumor group; Hematological tumors-PETHEMA, GELTAMO, CETLAM; Other and pediatric program-Spanish Pediatric Association,etc )- The outside collaborations of RTICC group are also reflected by the remarkable amount of competitive grant projects where RTICC researchers are frequently acting as PI.
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