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INTRODUCTION

Despite the significant progress made on cancer research during the last two decades, we still have the challenge of making an impact on the survival of cancer patients. In basic molecular oncology, this failure can be attributed to a number of historical problems associated to the type of research made in the field. Thus, most studies have been done at pre-clinical stages, a functional scenario that does not accurately reproduce the biological conditions faced by anti-cancer therapies in the context of fully developed primary tumor masses or metastasis. In addition, most of the research has been concentrated in the usual suspects and their direct downstream pathways. Such approach has limited the identification of alternative, unorthodox routes engaged by nodal oncogenic molecules. The search for drugs also faced a similar “spinning wheel” situation, thus limiting the therapeutic avenues that could be explored to interfere critical regulatory molecules of the tumorigenic process. Finally, there have been obvious gaps in the understanding of all the molecular alterations that contribute to cancer, a problem that is being solved by current international efforts to sequence the genomes of tumors. + more...

OBJECTIVES

INNOVATION AND TECHNOLOGY TRANSFER

SCIENTIFIC AND TECHNICAL COORDINATION

TECHNICAL PLATFORMS

ADDED VALUE TO BE OBTAINED FROM THE COOPERATIVE MMoC WORK

IMPACT AND TRANSFER

DISSEMINATION ACTIVITIES

EXPLOITATION OF RESULTS

SCHEME OF EVALUATION OF THE PROGRAMME

Introducción
Coordinador
Grupos
Work Packages
Publicaciones
Proyectos
Ensayos clínicos
Otros resultados
Agenda
Enlaces
Intranet
Noticias
03/03/2017 | Otras reuniones
13/11/2016 | Otras reuniones
Publicaciones
RD12/0036/0023
NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease.
Martinez D, Navarro A, Martinez-Trillos A, Molina-Urra R, Gonzalez-Farre B, Salaverria I, Nadeu F, Enjuanes A, Clot G, Costa D, Carrio A, Villamor N, Colomer D, Martinez A, Bens S, Siebert R, Wotherspoon A, Beà S, Matutes E, Campo E
Am J Surg Pathol  2016.  2.  192-201.  PMID: 26426381. 
Grupos colaboradores: RD12/0036/0036 , RD12/0036/0023

RD12/0036/0023
Present and future of personalized medicine in CLL.
Montserrat E, Bauman T, Delgado J
Best Pract Res Clin Haematol  2016.  1.  100-110.  PMID: 27742064. 

RD12/0036/0023
Maintenance therapy in chronic lymphocytic leukaemia.
Delgado J, Montserrat E
Lancet Haematol  2016.  9.  e399-400.  PMID: 27570083. 

RD12/0036/0023
[Advances in the treatment of chronic lymphocytic leukaemia].
Mozas P, Delgado J
Med Clin (Barc)  2016.  10.  447-454.  PMID: 27431885. 

RD12/0036/0023
The biology behind B-cell lymphoma 2 as a target in chronic lymphocytic leukemia.
Ortíz-Maldonado V, Mozas P, Delgado J
Ther Adv Hematol  2016.  6.  321-329.  PMID: 27904736. 

RD12/0036/0023
The European Hematology Association Roadmap for European Hematology Research: a consensus document.
Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, de Wit TD, Eichinger S, Fibbe W, Green T, de Haas F, Iolascon A, Jaffredo T, Rodeghiero F, Salles G, Schuringa JJ, EHA Roadmap for European Hematology Research.
Haematologica  2016.  2.  115-208.  PMID: 26819058. 

RD12/0036/0023
Diffuse Large B-Cell Lymphoma: Should Limited-Stage Patients Be Treated Differently?
Giné E, Sehn LH
Hematol Oncol Clin North Am  2016.  6.  1179-1194.  PMID: 27888874. 

RD12/0036/0023
Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage.
Queirós AC, Beekman R, Vilarrasa-Blasi R, Duran-Ferrer M, Clot G, Merkel A, Raineri E, Russiñol N, Castellano G, Beà S, Navarro A, Kulis M, Verdaguer-Dot N, Jares P, Enjuanes A, Calasanz MJ, Bergmann A, Vater I, Salaverría I, van de Werken HJ, Wilson WH, Datta A, Flicek P, Royo R, Martens J, Giné E, Lopez-Guillermo A, Stunnenberg HG, Klapper W, Pott C, Heath S, Gut IG, Siebert R, Campo E, Martín-Subero JI
Cancer Cell  2016.  5.  806-821.  PMID: 27846393. 
Grupos colaboradores: RD12/0036/0063 , RD12/0036/0036 , RD12/0036/0023

RD12/0036/0023
Genetic evolution in chronic lymphocytic leukaemia.
Delgado J, Villamor N, López-Guillermo A, Campo E
Best Pract Res Clin Haematol  2016.  1.  67-78.  PMID: 27742073. 
Grupos colaboradores: RD12/0036/0036 , RD12/0036/0023

RD12/0036/0020
FEMALE NEWBORN WITH UNDIFFERENTIATED SARCOMA DEFINED BY BCORCCNB3 FUSION TRANSCRIPT
Martín-Vañó S, Berbegall AP, Navarro L, Blanquer-Maceiras M, Beléndez-Bieler C, Garrido-Colino C, Navarro S, Rosa Noguera Salvá
  2015. 

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Red Temática Investigación Cooperativa en Cáncer (RTICC)
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