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RESEARCH ACTIVITY OF LUNG AND UPPER RESPIRATORY TRACT TUMORS PROGRAM

Work Plan. The scientific main goals of our proposal are to understand the biological intricacies of the disease in order to develop diagnostic, prognostic or predictive markers and more successful therapies. W e are also determined to optimize preventive strategies in lung cancer. To achieve these goals we have developed a work plan which includes 6 work packages (WPs).

WP1: Molecular mechanisms of respiratory tract carcinogenesis and metastasis

WP2: Molecular and genetic profiling of early stage and biomarkers

WP3: Discovery and preclinical validation of drug targets in LC.

WP4: New therapeutic strategies

WP5: Molecular and genetic profiling of metastatic disease for predicting response and resistance to conventional and novel treatments

WP6: Lung cancer prevention. Screening of lung cancer

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RD12/0036/0002
The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins.
Barreira M, Fabbiano S, Couceiro JR, Torreira E, Martínez-Torrecuadrada JL, Montoya G, Llorca O, Bustelo XR
Science signaling  2014.  321.  ra35.  PMID: 24736456. 

RD12/0036/0002
Role of Src homology domain binding in signaling complexes assembled by the murid ?-herpesvirus M2 protein.
Pires de Miranda M, Lopes FB, McVey CE, Bustelo XR, Simas JP
The Journal of biological chemistry  2013.  6.  3858-70.  PMID: 23258536. 

RD12/0036/0002
Coronin1 proteins dictate rac1 intracellular dynamics and cytoskeletal output.
Ojeda V, Castro-Castro A, Bustelo XR
Molecular and cellular biology  2014.  18.  3388-406.  PMID: 24980436. 

RD12/0036/0002
GENETIC DISSECTION OF THE Vav2-Rac1 SIGNALING AXIS IN VASCULAR SMOOTH MUSCLE CELLS.
Fabbiano S, Menacho-Márquez M, Sevilla MA, Albarrán-Juárez J, Zheng Y, Offermanns S, Montero MJ, Bustelo XR
Molecular and cellular biology  2014.  PMID: 25288640. 

RD12/0036/0002
Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease.
Larive RM, Moriggi G, Menacho-Márquez M, Cañamero M, Álava Ed, Alarcón B, Dosil M, Bustelo XR
Nature communications  2014.  3881.  PMID: 24826867. 

RD12/0036/0003
ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor.
Juliachs M, Castillo-Ávila W, Vidal A, Piulats JM, Garcia Del Muro X, Condom E, Hernández-Losa J, Teixidó C, Pandiella A, Graupera M, Casanovas O, Germà JR, Villanueva A, Viñals F
International journal of cancer. Journal international du cancer  2013.  1.  235-46.  PMID: 23292912. 

RD12/0036/0003
ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma.
Arias-González L, Moreno-Gimeno I, del Campo AR, Serrano-Oviedo L, Valero ML, Esparís-Ogando A, de la Cruz-Morcillo MÁ, Melgar-Rojas P, García-Cano J, Cimas FJ, Hidalgo MJ, Prado A, Callejas-Valera JL, Nam-Cha SH, Giménez-Bachs JM, Salinas-Sánchez AS, Pandiella A, del Peso L, Sánchez-Prieto R
Neoplasia (New York, N.Y.)  2013.  6.  649-59.  PMID: 23730213. 

RD12/0036/0003
The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma.
Rovida E, Di Maira G, Tusa I, Cannito S, Paternostro C, Navari N, Vivoli E, Deng X, Gray NS, Esparís-Ogando A, David E, Pandiella A, Dello Sbarba P, Parola M, Marra F
Gut  2014.  PMID: 25183205. 

RD12/0036/0003
Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer.
Montero JC, Esparís-Ogando A, Re-Louhau MF, Seoane S, Abad M, Calero R, Ocaña A, Pandiella A
Oncogene  2014.  2.  148-56.  PMID: 23246963. 

RD12/0036/0003
Phosphorylation of P-Rex1 at serine 1169 participates in IGF-1R signaling in breast cancer cells.
Montero JC, Seoane S, Pandiella A
Cellular signalling  2013.  11.  2281-9.  PMID: 23899556. 

ISCII
ISCII
 
Ministerio de Economia y Competitividad
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Red Temática Investigación Cooperativa Sanitaria
Rticc 2012
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ISCII
Red Temática Investigación Cooperativa en Cáncer (RTICC)
Centro de Investigación Cáncer - Campus Miguel de Unamuno - 37007 - Salamanca
(+34) 923294803 - sec.rticc[arroba]usal.es
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