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RESEARCH ACTIVITY OF LUNG AND UPPER RESPIRATORY TRACT TUMORS PROGRAM

Work Plan. The scientific main goals of our proposal are to understand the biological intricacies of the disease in order to develop diagnostic, prognostic or predictive markers and more successful therapies. W e are also determined to optimize preventive strategies in lung cancer. To achieve these goals we have developed a work plan which includes 6 work packages (WPs).

WP1: Molecular mechanisms of respiratory tract carcinogenesis and metastasis

WP2: Molecular and genetic profiling of early stage and biomarkers

WP3: Discovery and preclinical validation of drug targets in LC.

WP4: New therapeutic strategies

WP5: Molecular and genetic profiling of metastatic disease for predicting response and resistance to conventional and novel treatments

WP6: Lung cancer prevention. Screening of lung cancer

Grupos

Introducción
Coordinador
Grupos
Work Packages
Publicaciones
Proyectos
Ensayos clínicos
Otros resultados
Agenda
Enlaces
Intranet
Noticias
03/03/2017 | Otras reuniones
13/11/2016 | Otras reuniones
Publicaciones
RD12/0036/0031
Lynch syndrome caused by germline PMS2 mutations: delineating the cancer risk.
ten Broeke SW, Brohet RM, Tops CM, van der Klift HM, Velthuizen ME, Bernstein I, Capellá Munar G, Gomez Garcia E, Hoogerbrugge N, Letteboer TG, Menko FH, Lindblom A, Mensenkamp AR, Moller P, van Os TA, Rahner N, Redeker BJ, Sijmons RH, Spruijt L, Suerink M, Vos YJ, Wagner A, Hes FJ, Vasen HF, Nielsen M, Wijnen JT
J Clin Oncol  2015.  4.  319-25.  PMID: 25512458. 

RD12/0036/0031
The effect of genotypes and parent of origin on cancer risk and age of cancer development in PMS2 mutation carriers.
Suerink M, van der Klift HM, Ten Broeke SW, Dekkers OM, Bernstein I, Capellá Munar G, Gomez Garcia E, Hoogerbrugge N, Letteboer TG, Menko FH, Lindblom A, Mensenkamp A, Moller P, van Os TA, Rahner N, Redeker BJ, Olderode-Berends MJ, Spruijt L, Vos YJ, Wagner A, Morreau H, Hes FJ, Vasen HF, Tops CM, Wijnen JT, Nielsen M
Genet Med  2016.  4.  405-9.  PMID: 26110232. 

RD12/0036/0031
Delineating the Phenotypic Spectrum of the NTHL1-Associated Polyposis.
Belhadj S, Mur P, Navarro M, González S, Moreno V, Capellá G, Valle L
Clin Gastroenterol Hepatol  2016.  PMID: 27720914. 
Grupos colaboradores: RD12/0036/0009 , RD12/0036/0031

RD12/0036/0031
Mutanome and expression of immune response genes in microsatellite stable colon cancer.
Sanz-Pamplona R, Gil-Hoyos R, López-Doriga A, Alonso MH, Aussó S, Molleví DG, Santos C, Sanjuán X, Salazar R, Alemany R, Moreno V
Oncotarget  2016.  14.  17711-25.  PMID: 26871478. 

RD12/0036/0031
A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.
Vecchione L, Gambino V, Raaijmakers J, Schlicker A, Fumagalli A, Russo M, Villanueva A, Beerling E, Bartolini A, Mollevi DG, El-Murr N, Chiron M, Calvet L, Nicolazzi C, Combeau C, Henry C, Simon IM, Tian S, in 't Veld S, D'ario G, Mainardi S, Beijersbergen RL, Lieftink C, Linn S, Rumpf-Kienzl C, Delorenzi M, Wessels L, Salazar R, Di Nicolantonio F, Bardelli A, van Rheenen J, Medema RH, Tejpar S, Bernards R
Cell  2016.  2.  317-30.  PMID: 27058664. 

RD12/0036/0031
Gastrointestinal cancer: Light and shade of intrahepatic arterial radiotherapy in mCRC.
Tabernero J, Salazar R
Nat Rev Clin Oncol  2016.  8.  467-8.  PMID: 27296298. 
Grupos colaboradores: RD12/0036/0012 , RD12/0036/0031

RD12/0036/0031
Synthetic lethal interaction of cetuximab with MEK1/2 inhibition in NRAS-mutant metastatic colorectal cancer.
Queralt B, Cuyàs E, Bosch-Barrera J, Massaguer A, de Llorens R, Martin-Castillo B, Brunet J, Salazar R, Menendez JA
Oncotarget  2016.  PMID: 27636997. 

RD12/0036/0031
A novel germline POLE mutation causes an early onset cancer prone syndrome mimicking constitutional mismatch repair deficiency.
Wimmer K, Beilken A, Nustede R, Ripperger T, Lamottke B, Ure B, Steinmann D, Reineke-Plaass T, Lehmann U, Zschocke J, Valle L, Fauth C, Kratz CP
Fam Cancer  2016.  PMID: 27573199. 

RD12/0036/0031
Recent discoveries in the genetics of familial colorectal cancer and polyposis.
Valle L
Clin Gastroenterol Hepatol  2016.  PMID: 27712984. 

RD12/0036/0031
AMER1 Is a Frequently Mutated Gene in Colorectal Cancer--Letter.
Mur P, Aiza G, Sanz-Pamplona R, González S, Navarro M, Moreno V, Capellá G, Valle L
Clin Cancer Res  2015.  21.  4985.  PMID: 26527806. 

ISCII
ISCII
 
Ministerio de Economia y Competitividad
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Red Temática Investigación Cooperativa Sanitaria
Rticc 2012
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ISCII
Red Temática Investigación Cooperativa en Cáncer (RTICC)
Centro de Investigación Cáncer - Campus Miguel de Unamuno - 37007 - Salamanca
(+34) 923294803 - sec.rticc[arroba]usal.es
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