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Programas RTICC » Cáncer de colon » Introducción
 
INTRODUCTION

Colon cancer is the third most common cancer and the second cause of cancer death in developed countries. Colorectal cancer (CRC), when men and women are considered together, is the most frequent cancer in Spain, where every year more than 19,000 new cases are diagnosed. Nowadays, the life-time cumulative risk is about 6% and overall 5-year survival is around 50%, but this depends enormously on the stage at diagnosis. Prognosis is very poor for stage IV (20%), and these patients are treated with different lines of chemotherapy and targeted therapies than involve anti VEGF and EGFR treatments which are very expensive to the health care system. Pancreatic ductal adenocarcinoma is one of the most aggressive cancers and remains a largely incurable disease. It represents about 10% of all gastrointestinal malignancies, and it is the fourth leading cause of cancer death overall. It is the tumor in which less progress has been made at the clinical level in the last 50 years. Gastric cancer is currently the 5th leading cause of cancer-related death in both sexes, with rates of 12.94 and 5.65 in men and women, respectively in Spain with important geographic differences: some Spanish regions present mortality rates that are much higher than the European mean, while others show rates among the lowest in the continent. + more...

OBJECTIVES

EXCELLENCE, INNOVATION AND TECHNOLOGY TRANSFER

FUNCTIONAL STRUCTURE OF THE PROGRAMME

SYNERGIES

ADDED VALUE OF THE RESEARCH GROUPS

MANAGEMENT OF THE PROGRAM

IMPACT AND TRANSFER

SCHEME OF EVALUATION OF THE PROGRAMME

Timeline of tasks related to specific WPs

Introducción
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03/03/2017 | Otras reuniones
13/11/2016 | Otras reuniones
Publicaciones
RD12/0036/0012
Unveiling changes in the landscape of patient populations in cancer early drug development.
Hierro C, Azaro A, Argilés G, Elez E, Gómez P, Carles J, Rodon J
Oncotarget  2017.  8.  14158-14172.  PMID: 27835915. 

RD12/0036/0012
The expanding role of immunotherapy.
Martin-Liberal J, Ochoa de Olza M, Hierro C, Gros A, Rodon J, Tabernero J
Cancer Treat Rev  2017.  74-86.  PMID: 28231560. 

RD12/0036/0012
The consensus molecular subtypes of colorectal cancer.
Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, Bot BM, Morris JS, Simon IM, Gerster S, Fessler E, De Sousa E Melo F, Missiaglia E, Ramay H, Barras D, Homicsko K, Maru D, Manyam GC, Broom B, Boige V, Perez-Villamil B, Laderas T, Salazar R, Gray JW, Hanahan D, Tabernero J, Bernards R, Friend SH, Laurent-Puig P, Medema JP, Sadanandam A, Wessels L, Delorenzi M, Kopetz S, Vermeulen L, Tejpar S
Nat Med  2015.  11.  1350-6.  PMID: 26457759. 

RD12/0036/0012
Subgroup analysis in RAISE: a randomized, double-blind phase III study of irinotecan, folinic acid, and 5-fluorouracil (FOLFIRI) plus ramucirumab or placebo in patients with metastatic colorectal carcinoma progression.
Obermannová R, Van Cutsem E, Yoshino T, Bodoky G, Prausová J, Garcia-Carbonero R, Ciuleanu T, Garcia Alfonso P, Portnoy D, Cohn A, Yamazaki K, Clingan P, Lonardi S, Kim TW, Yang L, Nasroulah F, Tabernero J
Ann Oncol  2016.  11.  2082-2090.  PMID: 27573561. 

RD12/0036/0012
Single-cell transcriptome conservation in cryopreserved cells and tissues.
Guillaumet-Adkins A, Rodríguez-Esteban G, Mereu E, Mendez-Lago M, Jaitin DA, Villanueva A, Vidal A, Martinez-Marti A, Felip E, Vivancos A, Keren-Shaul H, Heath S, Gut M, Amit I, Gut I, Heyn H
Genome Biol  2017.  1.  45.  PMID: 28249587. 

RD12/0036/0012
Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients.
Sclafani F, Chau I, Cunningham D, Lampis A, Hahne JC, Ghidini M, Lote H, Zito D, Tabernero J, Glimelius B, Cervantes A, Begum R, De Castro DG, Wilson SH, Peckitt C, Eltahir Z, Wotherspoon A, Tait D, Brown G, Oates J, Braconi C, Valeri N
Carcinogenesis  2016.  9.  852-7.  PMID: 27381831. 

RD12/0036/0012
SEOM Clinical Guideline for the treatment of pancreatic cancer (2016).
Vera R, Dotor E, Feliu J, González E, Laquente B, Macarulla T, Martínez E, Maurel J, Salgado M, Manzano JL
Clin Transl Oncol  2016.  12.  1172-1178.  PMID: 27896637. 

RD12/0036/0012
Second-line therapy after nab-paclitaxel plus gemcitabine or after gemcitabine for patients with metastatic pancreatic cancer.
Chiorean EG, Von Hoff DD, Tabernero J, El-Maraghi R, Wee Ma W, Reni M, Harris M, Whorf R, Liu H, Shiansong Li J, Manax V, Romano A, Lu B, Goldstein D
Br J Cancer  2016.  9.  e13.  PMID: 27657342. 

RD12/0036/0012
Second-line therapy after nab-paclitaxel plus gemcitabine or after gemcitabine for patients with metastatic pancreatic cancer.
Chiorean EG, Von Hoff DD, Tabernero J, El-Maraghi R, Ma WW, Reni M, Harris M, Whorf R, Liu H, Li JS, Manax V, Romano A, Lu B, Goldstein D
Br J Cancer  2016.  2.  188-94.  PMID: 27351217. 

RD12/0036/0012
Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action.
Duran I, Lambea J, Maroto P, González-Larriba JL, Flores L, Granados-Principal S, Graupera M, Sáez B, Vivancos A, Casanovas O
Target Oncol  2017.  1.  19-35.  PMID: 27844272. 

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