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IARC study identifies new genetic factors linked to HPV-related cancers. Press Release N° 249

A new large-scale genetic study of head and neck cancers shows why some individuals infected with human papillomavirus (HPV) may go on to develop oropharyngeal cancer while others do not. Head and neck cancers are a related group of cancers that involve the oral cavity, pharynx (oropharynx, nasopharynx, and hypopharynx), and larynx.

The study, published today in Nature Genetics, identifies seven new genetic loci (locations of a gene on a chromosome): one that is linked to oropharyngeal cancer and six that are associated with oral cavity cancer, thus providing new insights into the development of these diseases.

The study, led by researchers from the International Agency for Research on Cancer (IARC) in partnership with 40 other research groups, compared about 6000 people with cancer of the oral cavity or pharynx (cases) with about 6000 people without the disease (controls). The researchers conducted extensive DNA analysis of more than 7 million variants for each individual.

The most prominent finding was an association between oropharyngeal cancer and genetic variation in the human leukocyte antigen (HLA) region, a genetic region important for regulation of the immune system.

One particular set of variants in the HLA region was associated with a more than 4-fold protective effect against developing oropharyngeal cancer associated with HPV infection. The same genetic variants have previously been shown to protect against cervical cancer, which is known to be associated with HPV infection.

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NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease.
Martinez D, Navarro A, Martinez-Trillos A, Molina-Urra R, Gonzalez-Farre B, Salaverria I, Nadeu F, Enjuanes A, Clot G, Costa D, Carrio A, Villamor N, Colomer D, Martinez A, Bens S, Siebert R, Wotherspoon A, Beà S, Matutes E, Campo E
Am J Surg Pathol  2016.  2.  192-201.  PMID: 26426381. 
Grupos colaboradores: RD12/0036/0036 , RD12/0036/0023

Present and future of personalized medicine in CLL.
Montserrat E, Bauman T, Delgado J
Best Pract Res Clin Haematol  2016.  1.  100-110.  PMID: 27742064. 

Maintenance therapy in chronic lymphocytic leukaemia.
Delgado J, Montserrat E
Lancet Haematol  2016.  9.  e399-400.  PMID: 27570083. 

[Advances in the treatment of chronic lymphocytic leukaemia].
Mozas P, Delgado J
Med Clin (Barc)  2016.  10.  447-454.  PMID: 27431885. 

The biology behind B-cell lymphoma 2 as a target in chronic lymphocytic leukemia.
Ortíz-Maldonado V, Mozas P, Delgado J
Ther Adv Hematol  2016.  6.  321-329.  PMID: 27904736. 

The European Hematology Association Roadmap for European Hematology Research: a consensus document.
Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, de Wit TD, Eichinger S, Fibbe W, Green T, de Haas F, Iolascon A, Jaffredo T, Rodeghiero F, Salles G, Schuringa JJ, EHA Roadmap for European Hematology Research.
Haematologica  2016.  2.  115-208.  PMID: 26819058. 

Diffuse Large B-Cell Lymphoma: Should Limited-Stage Patients Be Treated Differently?
Giné E, Sehn LH
Hematol Oncol Clin North Am  2016.  6.  1179-1194.  PMID: 27888874. 

Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage.
Queirós AC, Beekman R, Vilarrasa-Blasi R, Duran-Ferrer M, Clot G, Merkel A, Raineri E, Russiñol N, Castellano G, Beà S, Navarro A, Kulis M, Verdaguer-Dot N, Jares P, Enjuanes A, Calasanz MJ, Bergmann A, Vater I, Salaverría I, van de Werken HJ, Wilson WH, Datta A, Flicek P, Royo R, Martens J, Giné E, Lopez-Guillermo A, Stunnenberg HG, Klapper W, Pott C, Heath S, Gut IG, Siebert R, Campo E, Martín-Subero JI
Cancer Cell  2016.  5.  806-821.  PMID: 27846393. 
Grupos colaboradores: RD12/0036/0063 , RD12/0036/0036 , RD12/0036/0023

Genetic evolution in chronic lymphocytic leukaemia.
Delgado J, Villamor N, López-Guillermo A, Campo E
Best Pract Res Clin Haematol  2016.  1.  67-78.  PMID: 27742073. 
Grupos colaboradores: RD12/0036/0036 , RD12/0036/0023

Martín-Vañó S, Berbegall AP, Navarro L, Blanquer-Maceiras M, Beléndez-Bieler C, Garrido-Colino C, Navarro S, Rosa Noguera Salvá

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